Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bilirubin | inhibits the enzyme in a feedback regulation system, biliverdin inhibits the heme oxygenase activity, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + NAD+ | Homo sapiens | - |
biliverdin + NADH + H+ | - |
r | |
bilirubin + NAD+ | Rattus norvegicus | - |
biliverdin + NADH + H+ | - |
r | |
bilirubin + NADP+ | Homo sapiens | - |
biliverdin + NADPH + H+ | - |
r | |
bilirubin + NADP+ | Rattus norvegicus | - |
biliverdin + NADPH + H+ | - |
r | |
additional information | Homo sapiens | the enzyme shows dual cofactor- and pH-dependency in activity | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme shows dual cofactor- and pH-dependency in activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | BVR expression patterns, overview | Homo sapiens | - |
brain | co-expression with heme oxygenases HO-1 and HO-2, BVR expression patterns, overview | Rattus norvegicus | - |
brain cortex | - |
Rattus norvegicus | - |
cerebellum | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
additional information | the BVR activity progressively increases after birth and reaches adult levels by postpartum day 28 | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
substantia nigra | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + NAD+ | - |
Homo sapiens | biliverdin + NADH + H+ | - |
r | |
bilirubin + NAD+ | - |
Rattus norvegicus | biliverdin + NADH + H+ | - |
r | |
bilirubin + NADP+ | - |
Homo sapiens | biliverdin + NADPH + H+ | - |
r | |
bilirubin + NADP+ | - |
Rattus norvegicus | biliverdin + NADPH + H+ | - |
r | |
additional information | the enzyme shows dual cofactor- and pH-dependency in activity | Homo sapiens | ? | - |
? | |
additional information | the enzyme shows dual cofactor- and pH-dependency in activity | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BV reductase | - |
Homo sapiens |
BV reductase | - |
Rattus norvegicus |
BVR | - |
Homo sapiens |
BVR | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
the enzyme shows dual cofactor- and pH-dependency in activity | Homo sapiens |
additional information | - |
the enzyme shows dual cofactor- and pH-dependency in activity | Rattus norvegicus |
6.8 | - |
with NADH | Homo sapiens |
8.7 | - |
with NADPH | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme shows dual cofactor- and pH-dependency in activity | Homo sapiens | |
additional information | the enzyme shows dual cofactor- and pH-dependency in activity | Rattus norvegicus | |
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Rattus norvegicus | |
NADH | - |
Homo sapiens | |
NADH | - |
Rattus norvegicus | |
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | BVR expression is unaffected by heat shock | additional information |
Homo sapiens | BVR is induced by lipopolysaccharides and bromobenzene at a post-transcriptional level | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the heme oxygenase/biliverdin reductase axis is the main metabolic pathway for heme degradation. Activation during stress results in increased heme degradation and acceleration of biliverdin transformation to bilirubin | Homo sapiens |
metabolism | the heme oxygenase/biliverdin reductase axis is the main metabolic pathway for heme degradation. Activation suirng stress results in increased heme degradation and acceleration of biliverdin transformation to bilirubin | Rattus norvegicus |
additional information | pharmacodynamics of the heme oxygenase/biliverdin reductase system, overview | Homo sapiens |
physiological function | BV reductase regulates cell growth and apoptosis, its knockdown increases apoptosis. The BVR also phosphorylates the insulin receptor substrate 1, IRS-1, on serine residues preventing its phosphorylation by insulin receptor, which represent a physiological mechanism for increasing glucose uptake. And BVR is a nuclear transporter of ERK1/2 with metabolic regulatory role | Homo sapiens |
physiological function | BV reductase regulates cell growth and apoptosis, its knockdown increases apoptosis. The BVR also phosphorylates the insulin receptor substrate 1, IRS-1, on serine residues preventing its phosphorylation by insulin receptor, which represent a physiological mechanism for increasing glucose uptake. And BVR is a nuclear transporter of ERK1/2 with metabolic regulatory role | Rattus norvegicus |