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Literature summary for 1.3.1.24 extracted from

  • Kapitulnik, J.; Maines, M.D.
    Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin (2009), Trends Pharmacol. Sci., 30, 129-137.
    View publication on PubMed
Search for more literature for 1.3.1.24

Application

Application Comment Organism
medicine data gathered to date have identified the potential utility of hBVR in modulating cell signaling and the wide range of functions that are regulated by protein kinases that include growth, differentiation, gene transcription and metabolism, regulation of glucose uptake, induction of HO-1, and cytokine and Toll-like receptor signaling are potential target candidates for hBVR-based therapeutic strategies Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r

Subunits

Subunits Comment Organism
dimer hBVR in dimeric form binds to DNA Homo sapiens

Synonyms

Synonyms Comment Organism
biliverdin reductase
-
 Homo sapiens
BVR
-
 Homo sapiens
hBVR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens