Literature summary for 1.3.1.24 extracted from

Gafvels, M.; Holmstroem, P.; Somell, A.; Sjoevall, F.; Svensson, J.O.; Stahle, L.; Broome, U.; Stal, P.
A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice) (2009), Liver Int., 29, 1116-1124.

Search for more literature for 1.3.1.24

Application

Application	Comment	Organism
medicine	hyperbiliverdinaemia, green jaundice, with green plasma and urine may be caused by a genetic defect in the BVR-A gene in conjunction with decompensated liver cirrosis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
R18Stop	heterozygous nonsense mutation predicted to truncate the protein N-terminally to the active site tyrosine 97, discovered in nucleotide 52 of exon I of the DNA isolated from a hyperbiliverdinaemic patient	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
bilirubin + NADP+	Homo sapiens	-	biliverdin + NADPH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
bilirubin + NADP+	-	Homo sapiens	biliverdin + NADPH + H+	-	r

Synonyms

Synonyms	Comment	Organism
biliverdin reductase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)