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Literature summary for 1.3.1.24 extracted from

  • Tudor, C.; Lerner-Marmarosh, N.; Engelborghs, Y.; Gibbs, P.E.; Maines, M.D.
    Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin (2008), Biochem. J., 413, 405-416.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.24

Activating Compound

Activating Compound Comment Organism Structure
additional information BVR kinase activity is stimulated in the presence of double-stranded DNA fragments corresponding to HO-1 antioxidant and hypoxia response elements, as well as by haematin Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C281A/C292A/C293A mutant is defective for protein-protein-dependent interaction and haematin binding Homo sapiens
G17A mutant is defective for ATP binding Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus only kinase-competent BVR translocates to the nucleus Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin + NAD(P)H + H+
-
 Homo sapiens bilirubin + NAD(P)+
-
 ?

Synonyms

Synonyms Comment Organism
BVR BVR reduces biliverdin to the antioxidant bilirubin, functions as a kinase and as a transcription factor in the MAPK signalling cascade, as well as in the nuclear transport of haematin Homo sapiens
BVR-A isoform Homo sapiens
BVR-B isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)H
-
 Homo sapiens