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Literature summary for 1.3.1.24 extracted from
- Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization (1970), Biochemistry, 9, 298-303.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| albumin | - |
Cavia porcellus |
General Stability
| General Stability | Organism |
|---|---|
| repeated freeze-thawing: little loss of activity , no significant loss of activity, partially purified enzyme | Cavia porcellus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| albumin | - |
Cavia porcellus | |
| bilirubin | - |
Cavia porcellus |  |
| CuSO4 | - |
Cavia porcellus | |
| Fe2+ | - |
Cavia porcellus | |
| Fe3+ | - |
Cavia porcellus | |
| iodoacetate | - |
Cavia porcellus | |
| lipase | - |
Cavia porcellus | |
| p-hydroxymercuribenzoate | - |
Cavia porcellus | |
| Trypsin | - |
Cavia porcellus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biliverdin + NAD(P)H | Cavia porcellus | physiologic degradation of heme to bile pigments | bilirubin + NAD(P)+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| kidney | - |
Cavia porcellus | - |
| liver | - |
Cavia porcellus | - |
| muscle | low activity | Cavia porcellus | - |
| spleen | - |
Cavia porcellus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 8 weeks, 1-10 mg protein per ml, 5-25% loss of activity, partially purified enzyme | Cavia porcellus |
| 0°C, 8 weeks, 1-10 mg protein per ml, 15-25% loss of activity | Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| biliverdin + NAD(P)H | activity with NADPH is 50 times greater than with NADH | Cavia porcellus | bilirubin + NAD(P)+ | - |
? | |
| biliverdin + NAD(P)H | physiologic degradation of heme to bile pigments | Cavia porcellus | bilirubin + NAD(P)+ | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 56 | - |
5 min, complete loss of activity | Cavia porcellus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Cavia porcellus | |
| NADPH | - |
Cavia porcellus | |
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Release 2023.1 (January 2023)
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