Literature summary for 1.3.1.22 extracted from

Amory, J.K.; Wang, C.; Swerdloff, R.S.; Anawalt, B.D.; Matsumoto, A.M.; Bremner, W.J.; Walker, S.E.; Haberer, L.J.; Clark, R.V.
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men (2007), J. Clin. Endocrinol. Metab., 92, 1659-1665.

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Inhibitors

Inhibitors	Comment	Organism	Structure
dutasteride	0.5 mg/day, dual 5alpha-reductase inhibitor	Homo sapiens
finasteride	5.0 mg/day, effective inhibitor of type 2 5alpha-reductase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
testosterone + NADPH + H+	-	Homo sapiens	5alpha-dihydrotestosterone + NADP+ + H+	-	?

Synonyms

Synonyms	Comment	Organism
5alpha-reductase type 1	the isoenzyme predominates in the reproductive tissues, genital skin, and epididymis	Homo sapiens
5alpha-reductase type 2	the isoenzyme is predominantly found in the skin, liver, and testes	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)