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Literature summary for 1.3.1.22 extracted from

  • Cabeza, M.; Flores, E.; Heuze, I.; Sanchez, M.; Bratoeff, E.; Ramirez, E.; Francolugo, V.A.
    Novel 17 substituted pregnadiene derivatives as 5alpha-reductase inhibitors and their binding affinity for the androgen receptor (2004), Chem. Pharm. Bull., 52, 535-539.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-methylene-17alpha-(2-cyclohexylacetoxy)-pregn-4-ene-3,20-dione
-
Mesocricetus auratus
6-methylene-17alpha-(3-cyclohexylpropionyloxy)-pregn-4-ene-3,20-dione
-
Mesocricetus auratus
6-methylene-17alpha-(3-cyclopentylpropionyloxy)-pregn-4-ene-3,20-dione
-
Mesocricetus auratus
6-methylene-17alpha-(4-cyclohexylbutyryloxy)-pregn-4-ene-3,20-dione
-
Mesocricetus auratus
beta-sitosterol
-
Mesocricetus auratus
additional information synthesis and inhibitory potency of compounds, IC50 values, and affinity for the androgen receptor in prostate, overview Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mesocricetus auratus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
testosterone + NADPH + H+ Mesocricetus auratus
-
5alpha-dihydrotestosterone + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
golden hamster, male
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate from gonadectomized male hamster Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NADPH + H+
-
Mesocricetus auratus 5alpha-dihydrotestosterone + NADP+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mesocricetus auratus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
assay at Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mesocricetus auratus