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Literature summary for 1.3.1.21 extracted from

  • Zou, L.; Porter, T.D.
    Rapid suppression of 7-dehydrocholesterol reductase activity in keratinocytes by vitamin D (2015), J. Steroid Biochem. Mol. Biol., 148, 64-71.
    View publication on PubMed
Search for more literature for 1.3.1.21

General Stability

General Stability Organism
UVB irradiation does not affect enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
25-hydroxyvitamin D3
-
 Homo sapiens
cyclopamine treatment of adult human epidermal keratinocytes with 0.01 mM cyclopamine results in a decrease in enzyme activity (50% of control activity at 3 h) Homo sapiens
additional information not inhibited by 1alpha,25-dihydroxyvitamin D3 and vitamin D3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + NADP+ Homo sapiens
-
 cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
 Homo sapiens
-
HEKa cell human epidermal keratinocyte Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + NADP+
-
 Homo sapiens cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
Dhcr7
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens