Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme is induced when sterols are depleted both in vivo and in vitro | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
gene Dhcr7, chromosome mapping to 8q2.1, DNA and amino acid sequence determination and analysis of the full-length gene and the splicing variants Dhcr7-AS-1-5, gene structure, physical map, 5 alternative splicing variants | Rattus norvegicus |
gene Dhcr7, DNA and amino acid sequence determination and analysis, 1723 nucleotides, about 636 base pairs, gene structure, physical map, transcript half-life, alternative splicing variant 4 | Rattus norvegicus |
gene Dhcr7, DNA and amino acid sequence determination and analysis, gene structure, 1474 nucleotides, about 387 base pairs, physical map, transcript half-life, alternative splicing variant 1 | Rattus norvegicus |
gene Dhcr7, DNA and amino acid sequence determination and analysis, gene structure, 1595 nucleotides, about 508 base pairs, physical map, transcript half-life, alternative splicing variant 2 | Rattus norvegicus |
gene Dhcr7, DNA and amino acid sequence determination and analysis, no alternative splicing | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3beta-ol + NADPH | Rattus norvegicus | enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | Homo sapiens | enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | Mus musculus | enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol | cholesterol + NADP+ | - |
? | |
additional information | Mus musculus | enzyme is regulated through tissue-specific transcription and differential alternative splicing | ? | - |
? | |
additional information | Rattus norvegicus | enzyme is regulated through tissue-specific transcription and differential alternative splicing, enzyme is induced when sterols are depleted both in vivo and in vitro | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBM7 | enzyme Dhcr7, no additional isoforms, no alternative splicing | - |
Mus musculus | O88455 | 3 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7 | - |
Rattus norvegicus | Q9E2H5 | full-length gene, genomic DNA; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7, i.e. splicing variants Dhcr7-AS-1-5 | - |
Rattus norvegicus | Q9Z2Z8 | alternatively spliced variant 1, i.e. Dhcr7-AS-1; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7 | - |
Rattus norvegicus | Q9Z2Z8 | alternatively spliced variant 2, i.e. Dhcr7-AS-2; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7 | - |
Rattus norvegicus | Q9Z2Z8 | alternatively spliced variant 4, i.e. Dhcr7-AS-4; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
brain | mainly expressed in | Rattus norvegicus | - |
Hep-G2 cell | - |
Homo sapiens | - |
intestine | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
kidney | low expression level | Rattus norvegicus | - |
L-929 cell | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | mainly expressed in | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
additional information | developmental/age-related expression pattern of Dhcr7-AS-1 | Rattus norvegicus | - |
additional information | developmental/age-related expression pattern of Dhcr7-AS-2 | Rattus norvegicus | - |
additional information | splicing variants Dhcr7-AS-1-5 are differentially expressed in the tissues | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3beta-ol + NADPH | enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol | Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol | Homo sapiens | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol | Mus musculus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | i.e. 7-dehydrocholesterol | Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | i.e. 7-dehydrocholesterol | Homo sapiens | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | i.e. 7-dehydrocholesterol | Mus musculus | cholesterol + NADP+ | - |
? | |
additional information | enzyme is regulated through tissue-specific transcription and differential alternative splicing | Mus musculus | ? | - |
? | |
additional information | enzyme is regulated through tissue-specific transcription and differential alternative splicing, enzyme is induced when sterols are depleted both in vivo and in vitro | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dhcr7 | - |
Rattus norvegicus |
Dhcr7 | - |
Homo sapiens |
Dhcr7 | - |
Mus musculus |
Dhcr7-AS-1 | - |
Rattus norvegicus |
Dhcr7-AS-2 | - |
Rattus norvegicus |
Dhcr7-AS-4 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Mus musculus |