Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[p-(beta-Diethylaminoethoxy) phenyl]1-(p-tolyl)-2-(p-chlorophenyl)ethanol | i.e. MER-29 or triparanol | Rattus norvegicus | |
3beta-[2-(diethylamino)ethoxy]androst-5-en-17-one | i.e. U18666A | Rattus norvegicus | |
ergosterol | non-competetively, concentration 0.025 mM | Rattus norvegicus | |
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride | i.e. AY-9944, hypercholesterolaemic drug | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.21 | - |
ergosterol | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3-beta-ol + NADPH | Rattus norvegicus | - |
cholesterol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00011 | - |
testis enzyme, extract | Rattus norvegicus |
0.00108 | - |
solubilized by 1.5% 3-[3-(cholamidopropyl)-dimethylammonio]-1-propanesulfonate, i.e. CHAPS, from microsomes | Rattus norvegicus |
0.0023 | - |
liver enzyme, extract | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3-beta-ol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-7-en-3beta-ol + NADPH | low activity | Rattus norvegicus | ? | - |
? | |
cholesta-7-en-3beta-ol + NADPH | i.e. lathosterol | Rattus norvegicus | ? | - |
? | |
ergosta-5,7,22-trien-3beta-ol + NADPH | i.e. ergosterol | Rattus norvegicus | ergosta-5,22-diene-3beta-ol + NADP+ | - |
? | |
ergosta-5,7,22-trien-3beta-ol + NADPH | enzyme activity diet-inducible: 2.6fold by 0.5% ergosterol and 5fold by 5.0% cholestyramine and 0.1% lovastatin | Rattus norvegicus | ergosta-5,22-diene-3beta-ol + NADP+ | - |
? | |
ergosterol + NADP+ | - |
Rattus norvegicus | ? | - |
r |
Synonyms | Comment | Organism |
---|---|---|
sterol DELTA7-reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000109 | - |
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride | - |
Rattus norvegicus |