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Literature summary for 1.3.1.20 extracted from
- Rat liver microsomal 3alpha-hydroxysteroid dehydrogenase and dihydrodiol dehydrogenase: solubilization, separation and partial purification (1986), Biochem. Biophys. Res. Commun., 135, 795-801.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| indomethacin | cytosolic enzyme | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | Rattus norvegicus | - |
catechol + NAD(P)H | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
microsomes: dihydrodiol dehydrogenase and 3alpha-hydroxysteroid dehydrogenase are different enzymes, cytosol: dihydrodiol dehydrogenase and 3alpha-hydroxysteroid dehydrogenase activity is unseparable | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purified from microsomes | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | the cytosolic, but not the microsomal, enzyme is identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50 | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.62 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-acenaphthenol + NAD(P)+ | - |
Rattus norvegicus | ? | - |
? | |
| trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Rattus norvegicus | catechol + NAD(P)H | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
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