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Literature summary for 1.3.1.2 extracted from

  • Mattison, L.; Fourie, J.; Hirao, Y.; Koga, T.; Desmond, R.A.; King, J.R.; Shimizu, T.; Diasio, R.B.
    The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil (2006), Clin. Cancer Res., 12, 549-555.
    View publication on PubMed

Application

Application Comment Organism
medicine uracil breath test breath 13CO2 pharmacokinetics parallel plasma [2-13C]uracil and [2-13C]dihydrouracil pharmacokinetics and are an accurate measure of interindividual variation in enzyme activity. Data support the use of uracil breath test to identify enzyme deficiency before 5-fluorouracil-based therapy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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