Application | Comment | Organism |
---|---|---|
medicine | identification of mutants G366A and T768K in healthy Japanese volunteers. G366A results in marked decrease in enzyme affinity to NADPH, reduction of Vmax for 5-fluorouracil degrading activity, T768K leads to rapid loss of enzyme activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G366A | natural mutation, marked decrease in enzyme affinity to NADPH, reduction of Vmax for 5-fluorouracil degrading activity | Homo sapiens |
T768K | natural mutation identified in healthy Japanese volunteer, rapid loss of enzyme activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
healthy Japanese volunteers | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mononuclear cell | peripheral mononuclear cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADPH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |