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Literature summary for 1.3.1.2 extracted from

  • Ogura, K.; Ohnuma, T.; Minamide, Y.; Mizuno, A.; Nishiyama, T.; Nagashima, S.; Kanamaru, M.; Hiratsuka, A.; Watabe, T.; Uematsu, T.
    Dihydropyrimidine dehydrogenase activity in 150 healthy Japanese volunteers and identification of novel mutations (2005), Clin. Cancer Res., 11, 5104-5111.
    View publication on PubMed

Application

Application Comment Organism
medicine identification of mutants G366A and T768K in healthy Japanese volunteers. G366A results in marked decrease in enzyme affinity to NADPH, reduction of Vmax for 5-fluorouracil degrading activity, T768K leads to rapid loss of enzyme activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
G366A natural mutation, marked decrease in enzyme affinity to NADPH, reduction of Vmax for 5-fluorouracil degrading activity Homo sapiens
T768K natural mutation identified in healthy Japanese volunteer, rapid loss of enzyme activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
healthy Japanese volunteers
-

Source Tissue

Source Tissue Comment Organism Textmining
mononuclear cell peripheral mononuclear cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADPH + H+
-
Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens