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Literature summary for 1.3.1.2 extracted from
- Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver (1989), Biochem. Pharmacol., 38, 1471-1480.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-deazauracil | i.e. 2,6-pyridinediol | Mus musculus |  |
| 3-deazauracil | i.e. 2,4-pyridinediol | Mus musculus | |
| 5,6-dioxyuracil | i.e. alloxan | Mus musculus | |
| 5-benzyloxybenzyluracil | - |
Mus musculus | |
| 5-benzyluracil | - |
Mus musculus | |
| 5-nitrobarbituric acid | - |
Mus musculus | |
| additional information | - |
Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
extensive overview of literature data concerning inhibitors and substrates | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,6-dihydrouracil + NADP+ | - |
Mus musculus | uracil + NADPH | - |
r | |
| dihydrothymine + NADP+ | - |
Mus musculus | thymine + NADPH | - |
r | |
| additional information | - |
Mus musculus | ? | - |
? | |
| thymine + NADPH | - |
Mus musculus | dihydrothymine + NADP+ | - |
r | |
| uracil + NADPH | - |
Mus musculus | 5,6-dihydrouracil + NADP+ | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Mus musculus | |
| 0.0002 | - |
5-benzyloxybenzyluracil | - |
Mus musculus | |
| 0.0005 | - |
1-deazauracil | - |
Mus musculus | |
| 0.0021 | - |
3-deazauracil | - |
Mus musculus | |
| 0.0034 | - |
5-benzyluracil | - |
Mus musculus | |
| 0.0038 | - |
5-nitrobarbituric acid | - |
Mus musculus | |
| 0.0066 | - |
5,6-dioxyuracil | - |
Mus musculus | |
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