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Literature summary for 1.3.1.2 extracted from
- Dihydropyrimidine dehydrogenase activity in human blood mononuclear cells (1989), Enzyme, 42, 15-24.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | rate limiting enzyme for detoxification of exogenous fluoropyrimidines, antitumor drug design | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
thymine | - |
Homo sapiens |  |
| 0.01 | - |
NADPH | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + NADPH + H+ | Homo sapiens | - |
5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
| thymine + NADPH | Homo sapiens | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | dihydrothymine + NADP+ | - |
? | |
| thymine + NADPH | Homo sapiens | rate-limiting enzyme of thymidine and uridine degradation | dihydrothymine + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| mononuclear cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + NADPH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NADP+ | - |
? | |
| thymine + NADPH | - |
Homo sapiens | dihydrothymine + NADP+ | - |
? | |
| thymine + NADPH | rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines | Homo sapiens | dihydrothymine + NADP+ | - |
? | |
| thymine + NADPH | rate-limiting enzyme of thymidine and uridine degradation | Homo sapiens | dihydrothymine + NADP+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | contains 2 mol FMN and 2 mol FAD per mol of enzyme, tightly associated | Homo sapiens | |
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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