Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-(9H-fluoren-9-yl)piperazin-1-yl)(indolin-5-yl)methanone | i.e. Genz10850 | Mycobacterium tuberculosis | |
(4-benzylpiperidin-1-yl)(4-methylphenyl)methanone | - |
Mycobacterium tuberculosis | |
(4-benzylpiperidin-1-yl)(p-tolyl)methanone | - |
Mycobacterium tuberculosis | |
1-cyclohexyl-N-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide | - |
Mycobacterium tuberculosis | |
1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide | - |
Mycobacterium tuberculosis | |
1-cyclohexyl-N-(5'-hydroxy-[1,1':4',1''-terphenyl]-2'-yl)-5-oxopyrrolidine-3-carboxamide | - |
Mycobacterium tuberculosis | |
4-(trifluoromethyl)-2-(4,5-dihydro-4-(2,4-dinitrophenyl)pyrazol-1-yl)pyrimidine | i.e. Genz8575 | Mycobacterium tuberculosis | |
5-butyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis | |
5-ethyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis | |
5-hexyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis | |
5-octyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis | |
5-pentyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis | |
5-tetradecyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis | |
Ethionamide | the prodrug requires activation by EthA, a flavin-dependent monooxygenase. According to the crystal structure of InhA with bound ethionamide-NAD adduct, the ethyl-isonicotinic-acyl moiety is located in a hydrophobic pocket formed by the rearrangement of the side chain of Phe149, and an aromatic ringstacking interaction with the pyridine ring | Mycobacterium tuberculosis | |
isoniazid | as a pro-drug, isoniazid requires activation by KatG, a catalase-peroxidase enzyme with dual activities of catalase and peroxidase oxidizing isoniazid to an acyl radical binding to position 4 of nicotinamide adenine dinucleotide (NAD) to form an active isoniazid-NAD adduct. Addition of the isonicotinoyl radical to position 4 of the nicotinamide ring can result in two stereoisomersi n which only 4(S) isomers of isoniazid-NAD adduct possess potent activity | Mycobacterium tuberculosis | |
N-([1,1'-biphenyl]-4-yl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide | - |
Mycobacterium tuberculosis | |
prothionamide | the prodrug requires activation by EthA, a flavin-dependent monooxygenase. According to the crystal structure of InhA with bound prothionamide-NAD adduct, the propyl-isonicotinic-acyl moiety is located in a hydrophobic pocket formed by the rearrangement of the side chain of Phe149, and an aromatic ringstacking interaction with the pyridine ring | Mycobacterium tuberculosis | |
triclosan | uncompetitive inhibitor | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WGR1 | - |
- |
Mycobacterium tuberculosis ATCC 25618 | P9WGR1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
InhA | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000011 | - |
5-octyl-2-phenoxyphenol | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.0000094 | - |
5-hexyl-2-phenoxyphenol | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.0000118 | - |
5-pentyl-2-phenoxyphenol | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.00003 | - |
5-tetradecyl-2-phenoxyphenol | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.0002 | - |
triclosan | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001005 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-cyclohexyl-N-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide | |
0.00014 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-cyclohexyl-N-(5'-hydroxy-[1,1':4',1''-terphenyl]-2'-yl)-5-oxopyrrolidine-3-carboxamide | |
0.00039 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide | |
0.00039 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | N-([1,1'-biphenyl]-4-yl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide | |
0.00516 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (4-benzylpiperidin-1-yl)(p-tolyl)methanone |