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Literature summary for 1.3.1.118 extracted from

  • Marrakchi, H.; Laneelle, G.; Quemard, A.
    InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II (2000), Microbiology, 146, 289-296 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-hexadecynoyl-CoA
-
Mycobacterium tuberculosis
2-octadecynoyl-CoA
-
Mycobacterium tuberculosis
isoniazid acts on the mycobacterial cell wall by preventing the FAS-II system from producing long-chain fatty acid precursors for mycolic acid biosynthesis Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis mc(2)155
-
-
-

Synonyms

Synonyms Comment Organism
2-trans-enoyl-acyl carrier protein reductase
-
Mycobacterium tuberculosis
InhA
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Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism InhA belongs to the FAS-II system and participates in the mycolic acid pathway. The long-chain fatty acids produced by the FAS-II system serve as precursors for the formation of the meromycolic acids, which represent the C40-C60 main chain of mycolic acids Mycobacterium tuberculosis