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Literature summary for 1.3.1.118 extracted from

  • Joshi, S.; Dixit, S.; Basha, J.; Kulkarni, V.; Aminabhavi, T.; Nadagouda, M.; Lherbet, C.
    Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis (2018), Bioorg. Chem., 81, 440-453 .
    View publication on PubMed
Search for more literature for 1.3.1.118

Cloned(Commentary)

Cloned (Comment) Organism
expression of InHA-6xHis protein in Escherichia coli (BL21) Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking studies are performed on the crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with 1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
N-(2,3-dichlorophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
N-(2-aminophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
N-(2-nitrophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
N-(3-fluorophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
N-(4-chlorophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WGR1
-
-
Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis dodecanoyl-CoA + NAD+
-
 ?
trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis H37Rv dodecanoyl-CoA + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
 Mycobacterium tuberculosis
InhA
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the enzyme is involved in type II fatty acid biosynthetic pathway Mycobacterium tuberculosis