Literature summary for 1.3.1.1 extracted from

Li, Y.; Mizutani, Y.; Shiraishi, T.; Nakamura, T.; Mikami, K.; Takaha, N.; Okihara, K.; Kawauchi, A.; Sakai, T.; Miki, T.
The significance of the expression of dihydropyrimidine dehydrogenase in prostate cancer (2007), BJU Int., 99, 663-668.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-chloro-2,4-dihydroxypyridine	potent inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DU-145 cell	-	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-
prostate cancer cell	-	Homo sapiens	-
prostate gland	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorouracil + NADH + H+	-	Homo sapiens	5-fluoro-5,6-dihydrouracil + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
dihydropyrimidine dehydrogenase	-	Homo sapiens
DPD	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)