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Literature summary for 1.21.99.4 extracted from

  • Barca-Mayo, O.; Liao, X.H.; DiCosmo, C.; Dumitrescu, A.; Moreno-Vinasco, L.; Wade, M.S.; Sammani, S.; Mirzapoiazova, T.; Garcia, J.G.; Refetoff, S.; Weiss, R.E.
    Role of type 2 deiodinase in response to acute lung injury (ALI) in mice (2011), Proc. Natl. Acad. Sci. USA, 108, E1321-E1329.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information exposure of animals to ventilator-induced lung injury leads to ignificant increases in enzyme immunorectivity and activity. Treatment of knock-out mice with 3,3',5-triiodothyronine reverses many of the lung chemokine and cytokine profiles seen in response to ventilator-induced lung injury Mus musculus

Application

Application Comment Organism
medicine exposure of animals to ventilator-induced lung injury leads to ignificant increases in enzyme immunorectivity and activity. Treatment of knock-out mice with 3,3',5-triiodothyronine reverses many of the lung chemokine and cytokine profiles seen in response to ventilator-induced lung injury Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function enzyme knock-out mice exhibit greater susceptibility to ventilator-induced lung injury than wild-type mice, as evidenced by poorer alveoli integrity and quantified by lung chemokine and cytokine mRNA induction Mus musculus