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Literature summary for 1.21.99.4 extracted from

  • Wang, Y.Y.; Morimoto, S.; Du, C.K.; Lu, Q.W.; Zhan, D.Y.; Tsutsumi, T.; Ide, T.; Miwa, Y.; Takahashi-Yanaga, F.; Sasaguri, T.
    Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy (2010), Cardiovasc. Res., 87, 636-646.
    View publication on PubMed
Search for more literature for 1.21.99.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Mus musculus
-
 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
liver
-
 Mus musculus
-
myocardium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2
-
 Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
DIO2
-
 Mus musculus
type 2 iodothyronine deiodinase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus type 2 iodothyronine deiodinase (Dio2) is up-regulated in dilated cardiomyopathy mice hearts whereas the expression of type 1 iodothyronine deiodinase remains unchanged. Dio2 gene expression is also markedly up-regulated in the mice hearts developing similar eccentric hypertrophy after myocardial infarction up

General Information

General Information Comment Organism
physiological function Dio2 up-regulation is involved in cardiac remodelling in dilated cardiomyopathy through activating the thyroid hormone-signalling pathways involving Akt and p38 MAPK Mus musculus