Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.21.99.4 extracted from

  • Ohguchi, H.; Tanaka, T.; Uchida, A.; Magoori, K.; Kudo, H.; Kim, I.; Daigo, K.; Sakakibara, I.; Okamura, M.; Harigae, H.; Sasaki, T.; Osborne, T.F.; Gonzalez, F.J.; Hamakubo, T.; Kodama, T.; Sakai, J.
    Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9 (2008), Mol. Cell. Biol., 28, 3917-3931.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
thyroid hormone
-
Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
a promoter reporter gene for a luciferase assay is constructed Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
amiodarone
-
Mus musculus
propylthiouracil
-
Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
selenium
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Mus musculus isoenzyme Dio1 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
?
L-thyroxine + AH2 Mus musculus
-
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61153
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 isoenzyme Dio1 Mus musculus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
?
L-thyroxine + AH2
-
Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
DIO1
-
Mus musculus
type 1 iodothyronine deiodinase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
activity assay Mus musculus

Expression

Organism Comment Expression
Mus musculus expression of the Dio1 gene is dependent on HNF4alpha expression, the Dio1 promoter is directly regulated by HNF4alpha down
Mus musculus expression of the Dio1 gene is dependent on HNF4alpha expression, the Dio1 promoter is directly regulated by HNF4alpha, the Krüppel-like transcription factor 9, KLF9, functions together with HNF4alpha and GATA4 to synergistically activate the promoter through direct interaction between these transcriptional factors up