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Literature summary for 1.21.99.4 extracted from

  • Celi, F.S.; Coppotelli, G.; Chidakel, A.; Kelly, M.; Brillante, B.A.; Shawker, T.; Cherman, N.; Feuillan, P.P.; Collins, M.T.
    The role of type 1 and type 2 5-deiodinase in the pathophysiology of the 3,5,3-triiodothyronine toxicosis of McCune-Albright syndrome (2008), J. Clin. Endocrinol. Metab., 93, 2383-2389.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.21.99.4

Inhibitors

Inhibitors Comment Organism Structure
propylthiouracil D1 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Homo sapiens
-
 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
parenchyma of thyroid gland thyroid tissue samples are collected from five patients, three affected by toxic nodule, and from areas of normal thyroid parenchyma from five patients undergoing total thyroidectomy for thyroid cancer Homo sapiens
-
thyroid gland
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000000058
-
 normal tissues Homo sapiens
0.0000000286
-
 normal tissues Homo sapiens
0.0000000429
-
 McCune-Albright syndrome patients Homo sapiens
0.0000000543
-
 toxic adenoma patient Homo sapiens
0.0000000714
-
 toxic adenoma patient Homo sapiens
0.0000001857
-
 McCune-Albright syndrome patients Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2
-
 Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
D1 5'-deiodinase
-
 Homo sapiens
D2 5'-deiodinase
-
 Homo sapiens
type 1 5'-deiodinase
-
 Homo sapiens
type 2 5'-deiodinase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 5'-deiodinase is increased in McCune-Albright syndrome-associated hyperthyroidism pathogenesis up