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Literature summary for 1.21.99.4 extracted from

  • Lamirand, A.; Mercier, G.; Ramauge, M.; Pierre, M.; Courtin, F.
    Hypoxia stabilizes type 2 deiodinase activity in rat astrocytes (2007), Endocrinology, 148, 4745-4753.
    View publication on PubMed
Search for more literature for 1.21.99.4

Activating Compound

Activating Compound Comment Organism Structure
carbobenzoxy-L-leucyl-L-leucyl-L-leucinal MG132, proteasome inhibitor, increases type 2 deiodinase Rattus norvegicus
forskolin increases mRNA expression and type 2 deiodinase activity, hypoxia stimulates forskolin induces activation of type 2 deiodinase Rattus norvegicus
additional information hypoxia activates type 2 deiodinase by a posttranslational mechanism, glucose depletion decrased hypoxia induced type 2 deiodinase activation, agents promoting hypoxia like desferrioxamine, dimethyloxalylglycine, diethylsuccinatecobalt chloride activate type 2 deiodinase Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
3,3',5,5'-tetraiodo-L-thyronine hypoxia has no effect on inhibition of T4 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cell culture Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000000003
-
 medium alone Rattus norvegicus
0.0000000006
-
 hypoxia Rattus norvegicus
0.000000025
-
 in presence of carbobenzoxy-L-leucyl-L-leucyl-L-leucinal Rattus norvegicus
0.00000003
-
 10 micromol forskolin Rattus norvegicus
0.00000009
-
 10 micromol forskolin and hypoxia Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 addition of I125 labelled T4 to measure the production of T3, using paper chromatography Rattus norvegicus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
type 2 deiodinase
-
 Rattus norvegicus