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Literature summary for 1.21.99.4 extracted from

  • Koehrle, J.; Auf'mkolk, M.; Rokos, H.; Hesch, R.D.; Cody, V.
    Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site (1986), J. Biol. Chem., 261, 11613-11622.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoic acid comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3',5'-diiodothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,3',5'-triiodothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,5,3'-triiodo-5'-nitrothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,5,5'-triiodo-2'-methylthyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,5-diiodo-2'-hydroxythyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,5-diiodo-3',5'-dinitrothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,5-diiodo-3'-hydroxythyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
3,5-diiodo-4'-amino-3',5'-dimethylthyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
N-acetyl-3,5,3'-triiodo-5'-nitrothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
Tetraiodothyroacetic acid comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid comparison with 5-deiodinase EC 1.97.1.11 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
L-thyroxine pH 7.4, 37°C Rattus norvegicus
0.01
-
3,5'-diiodo-L-thyronine pH 7.4, 37°C Rattus norvegicus
0.02
-
3,3',5'-triiodo-L-thyronine pH 7.4, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodo-L-thyronine + AH2 Rattus norvegicus
-
3,3'-diiodothyronine + iodide + A + H+
-
?
3,5'-diiodo-L-thyronine + AH2 Rattus norvegicus
-
3-iodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2 Rattus norvegicus
-
3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?
additional information Rattus norvegicus L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodo-L-thyronine + AH2
-
Rattus norvegicus 3,3'-diiodothyronine + iodide + A + H+
-
?
3,5'-diiodo-L-thyronine + AH2
-
Rattus norvegicus 3-iodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2
-
Rattus norvegicus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?
additional information L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway Rattus norvegicus ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
pH 7.4, 37°C Rattus norvegicus Tetraiodothyroacetic acid
0.0003
-
pH 7.4, 37°C Rattus norvegicus 3,3',5'-triiodothyronine
0.0003
-
pH 7.4, 37°C Rattus norvegicus [4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
0.0005
-
pH 7.4, 37°C Rattus norvegicus [4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetate
0.0008
-
pH 7.4, 37°C Rattus norvegicus [4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid
0.001
-
pH 7.4, 37°C Rattus norvegicus 3',5'-diiodothyronine
0.0015
-
pH 7.4, 37°C Rattus norvegicus N-acetyl-3,5,3'-triiodo-5'-nitrothyronine
0.0015
-
pH 7.4, 37°C Rattus norvegicus [4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid
0.002
-
pH 7.4, 37°C Rattus norvegicus ethyl 4-(4-hydroxy-3,5-diiodobenzoyl)phenyl carbonate
0.003
-
-
Rattus norvegicus 2-amino-3-[4-[(4-hydroxy-3,5-diiodophenyl)thio]-3,5-diiodophenyl]propanoate
0.004
-
pH 7.4, 37°C Rattus norvegicus N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine
0.007
-
pH 7.4, 37°C Rattus norvegicus 3,5,5'-triiodo-2'-methylthyronine
0.007
-
pH 7.4, 37°C Rattus norvegicus N-acetyl-3,5-diiodo-3',5'-dinitrothyronine
0.008
-
pH 7.4, 37°C Rattus norvegicus 3,5,3'-triiodo-5'-nitrothyronine
0.008
-
pH 7.4, 37°C Rattus norvegicus 3,5-diiodo-2'-hydroxythyronine
0.012
-
pH 7.4, 37°C Rattus norvegicus 3,5-diiodo-4'-amino-3',5'-dimethylthyronine
0.013
-
pH 7.4, 37°C Rattus norvegicus 3,5-diiodo-3'-hydroxythyronine
0.014
-
pH 7.4, 37°C Rattus norvegicus 3,5-diiodo-3',5'-dinitrothyronine