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Literature summary for 1.21.99.3 extracted from

  • Huang, S.A.; Dorfman, D.M.; Genest, D.R.; Salvatore, D.; Larsen, P.R.
    Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium (2003), J. Clin. Endocrinol. Metab., 88, 1384-1388.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Se selenoenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic epithelium fetal Homo sapiens
-
cytotrophoblast
-
Homo sapiens
-
decidua
-
Homo sapiens
-
endothelium of fetal vessels Homo sapiens
-
respiratory epithelium fetal Homo sapiens
-
syncytiotrophoblast
-
Homo sapiens
-
umbilical artery
-
Homo sapiens
-
umbilical vein
-
Homo sapiens
-
urinary tract epithelium Homo sapiens
-
uterine endometrium of nonpregnant human uteri Homo sapiens
-
uterus endometrial gland Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triido-L-thyronine + AH
-
Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2
-
Homo sapiens 3,3',5'-triido-L-thyronine + iodide + A + H+
-
?
additional information the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
type 3 iodothyronine deiodinase
-
Homo sapiens