Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aurothioglucose | 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity | Homo sapiens | |
iopanoic acid | 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity | Homo sapiens | |
additional information | no inhibition of 5-deiodinase activity by propylthiouracil | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000107 | - |
L-thyroxine | pH 8.0, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
5-deiodinase activity | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocytoma cell | - |
Homo sapiens | - |
brain cancer cell | 5-deiodinase activity | Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
lymphoma cell | malignant | Homo sapiens | - |
medulloblastoma cell | - |
Homo sapiens | - |
meningioma cell | - |
Homo sapiens | - |
oligodendroglioma cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity in brain carcinoma types | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | 5-deiodinase activity | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
70 | - |
30 min, inactivation of 5-deiodinase | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
3,3',5,5'-tetraiodo-L-thyronine 5deiodinase activity | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | absolutely required | Homo sapiens | |
dithiothreitol | optimal at 50-100 mM | Homo sapiens |