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Literature summary for 1.21.99.3 extracted from

  • Tanaka, K.; Shimatsu, A.; Imura, H.
    Iodothyronine 5-deiodinase in rat posterior pituitary (1992), Biochem. Biophys. Res. Commun., 188, 272-277.
    View publication on PubMed
Search for more literature for 1.21.99.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Rattus norvegicus 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats
-
Rattus norvegicus
-
 isozyme type III
-
Rattus norvegicus
-
 isozyme type II
-
Rattus norvegicus
-
 isozyme type I
-

Source Tissue

Source Tissue Comment Organism Textmining
pituitary gland posterior Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000024
-
 3,3',5-triiodo-L-thyronine 5-deiodination activity, isozyme type III, posterior pituitary gland Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5-triiodo-L-thyronine + AH2 best substrate Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5'-deiodinase activity Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 isozyme type II Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 isozyme type I Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
additional information isozyme type III predominantly performs 5-deiodination reactions, while isozymes type I and type II perform 5'-deiodination reactions Rattus norvegicus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5 isozyme type III, 3,3',5-triiodo-L-thyronine 5-deiodinase activity Rattus norvegicus