Activating Compound | Comment | Organism | Structure |
---|---|---|---|
PqqD | PqqE activity is dependent on the accessory protein PqqD. The intramolecular cross-linking reaction that occurs between PqqA residues is dependent on PqqE, the peptide chaperone PqqD, and the flavodoxin reductase system | Methylorubrum extorquens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a PqqA peptide + S-adenosyl-L-methionine | Methylorubrum extorquens | - |
a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | - |
? | |
a PqqA peptide + S-adenosyl-L-methionine | Methylorubrum extorquens ATCC 14718 | - |
a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methylorubrum extorquens | P71517 | - |
- |
Methylorubrum extorquens ATCC 14718 | P71517 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a PqqA peptide + S-adenosyl-L-methionine | - |
Methylorubrum extorquens | a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | - |
? | |
a PqqA peptide + S-adenosyl-L-methionine | the enzyme catalyzes the carbon-carbon bond formation between a Glu15 and Tyr19 side chain within the small peptide substrate PqqA. Intramolecular cross-linking reaction between PqqA residues | Methylorubrum extorquens | a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | - |
? | |
a PqqA peptide + S-adenosyl-L-methionine | - |
Methylorubrum extorquens ATCC 14718 | a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | - |
? | |
a PqqA peptide + S-adenosyl-L-methionine | the enzyme catalyzes the carbon-carbon bond formation between a Glu15 and Tyr19 side chain within the small peptide substrate PqqA. Intramolecular cross-linking reaction between PqqA residues | Methylorubrum extorquens ATCC 14718 | a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pqqE | - |
Methylorubrum extorquens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
iron-sulfur centre | the enzyme contains three Fe-S centers, at least two of which are present as [4Fe-4S]. PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S]+ clusters | Methylorubrum extorquens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the pyrroloquinoline quinone biosynthetic pathway | Methylorubrum extorquens |