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Literature summary for 1.21.3.1 extracted from

  • Ge, W.; Clifton, I.J.; Stok, J.E.; Adlington, R.M.; Baldwin, J.E.; Rutledge, P.J.
    Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase? (2008), J. Am. Chem. Soc., 130, 10096-10102.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structures of isopenicillin N synthase in complex with L-alpha-aminoadipoyl-L-cysteine (1-(S)-carboxy-2-thiomethyl)ethyl ester and FeII exposed to O2 and unexposed to O2 are determined to 1.4 and 1.8 A resolutions, respectively Aspergillus nidulans

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2 Aspergillus nidulans
-
isopenicillin N + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
delta-L-alpha-aminoadipoyl-L-cysteine (1-(S)-carboxy-2-thiomethyl)ethyl ester + O2 substrate analogue Aspergillus nidulans ? + H2O
-
?
L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2
-
Aspergillus nidulans isopenicillin N + 2 H2O
-
?
additional information iron-mediated conversion of metal-bound thiolate to sulfenate in crystallographic studies Aspergillus nidulans ?
-
?

Synonyms

Synonyms Comment Organism
IPNS
-
Aspergillus nidulans
isopenicillin N synthase
-
Aspergillus nidulans