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Literature summary for 1.21.3.1 extracted from
- The mechanism for isopenicillin N synthase from density-functional modeling highlights the similarities with other enzymes in the 2-His-1-carboxylate family (2008), Biochemistry, 47, 1031-1042.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | isopenicillin N synthase is a potential target in the design of novel antibiotic compounds | Aspergillus nidulans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D216E | mutant, retains 1% activity | Aspergillus nidulans |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | - |
Aspergillus nidulans |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2 | Aspergillus nidulans | - |
? + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus nidulans | - |
inital coordinates for computational calculations are taken from X-ray structure 1BLZ | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2 | - |
Aspergillus nidulans | ? + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IPNS | - |
Aspergillus nidulans |
| isopenicillin N synthase | - |
Aspergillus nidulans |
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Release 2023.1 (January 2023)
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