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Literature summary for 1.21.3.1 extracted from

  • Daruzzaman, A.; Clifton, I.J.; Adlington, R.M.; Baldwin, J.E.; Rutledge, P.J.
    Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase (2006), Chembiochem, 7, 351-358.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with substrate analogue delta-(L-alpha-aminoadipoyl)-(3R)-methyl-L-cysteine D-alpha hydroxyvaleryl ester, crystallization with anaerobic conditions and exposure of crystals to oxygen giving a hydroxymethyl/ene product. Discussion of steric and electronic effects around the valinyl isopropyl side chain of the enzyme’s active side Aspergillus nidulans

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans P05326
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
delta-(L-alpha-aminoadipoyl)-(3R)-methyl-L-cysteine D-alpha hydroxyvaleryl ester + O2
-
Aspergillus nidulans ? + H2O
-
?