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Literature summary for 1.20.99.1 extracted from
- Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 A and 2.03 A (2001), Structure, 9, 125-132.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | induction by arsenite | Alcaligenes faecalis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| X-ray diffraction structure determination and analysis of 2 different crystal forms at 1.64-2.03 A using multiple isomorphous replacement with anomalous scattering and multiple-wavelength anomalous dispersion methods | Alcaligenes faecalis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | enzyme is a MoFe protein, Mo atom bound to 2 pterin cofactors and a [3Fe4S] cluster, binding site on the large subunit, the small subunit contains a binding site for a Rieske-type [2Fe2S] cluster | Alcaligenes faecalis |  |
| Molybdenum | enzyme is a MoFe protein, Mo atom bound to 2 pterin cofactors and a [3Fe4S] cluster, binding site on the large subunit, the Mo atom is not covalently bound to the polypeptide | Alcaligenes faecalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arsenite + acceptor | Alcaligenes faecalis | detoxification of arsenite to the less toxic arsenate prior to methylation | arsenate + reduced acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Alcaligenes faecalis | - |
NCIB 8687 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arsenite + acceptor | - |
Alcaligenes faecalis | arsenate + reduced acceptor | - |
? | |
| arsenite + acceptor | detoxification of arsenite to the less toxic arsenate prior to methylation | Alcaligenes faecalis | arsenate + reduced acceptor | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | large subunit of 825 amino acid residues and a small subunit of 134 amino acid residues | Alcaligenes faecalis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arsenite oxidase | - |
Alcaligenes faecalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Pterin molybdenum cofactor | enzyme is a MoFe protein, Mo atom bound to 2 pterin cofactors and a [3Fe4S] cluster, binding site on the large subunit | Alcaligenes faecalis | |
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Release 2023.1 (January 2023)
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