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Literature summary for 1.20.4.3 extracted from

  • Rosado, L.A.; Wahni, K.; Degiacomi, G.; Pedre, B.; Young, D.; de la Rubia, A.G.; Boldrin, F.; Martens, E.; Marcos-Pascual, L.; Sancho-Vaello, E.; Albesa-Jove, D.; Provvedi, R.; Martin, C.; Makarov, V.; Versees, W.; Verniest, G.; Guerin, M.E.; Mateos, L.M.; Manganelli, R.; Messens, J.
    The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis (2017), J. Biol. Chem., 292, 13097-13110 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.20.4.3

Protein Variants

Protein Variants Comment Organism
C19S inactive Mycobacterium tuberculosis
C22S the mutant displays a slightly higher reducing activity toward mixed disulfides compared to the wild type enzyme Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis O53193
-
-
Mycobacterium tuberculosis H37Rv O53193
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties Mycobacterium tuberculosis ?
-
 ?
additional information the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

Subunits Comment Organism
? 2 * 23086, liquid chromatography-mass spectrometry Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
Mrx2
-
 Mycobacterium tuberculosis
mycoredoxin-2
-
 Mycobacterium tuberculosis
mycothiol-dependent reductase
-
 Mycobacterium tuberculosis
Rv2466c
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function the enzyme is essential for bacterial survival under H2O2 stress Mycobacterium tuberculosis