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Literature summary for 1.2.7.7 extracted from

  • Kletzin, A.; Adams, M.W.W.
    Molecular and phylogenetic chararcterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima (1996), J. Bacteriol., 178, 248-257.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.7.7

Activating Compound

Activating Compound Comment Organism Structure
thiamine diphosphate requires for maximal activity of enzyme Pyrococcus furiosus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Pyrococcus furiosus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe each of the tetramer contains three [4Fe-4S] cluster Pyrococcus furiosus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
11851
-
 alpha,beta,gamma,delta, x * 43960 + x * 34766 + x * 20033 + x * 11851, SDS PAGE, amino acid sequences Pyrococcus furiosus
20033
-
 alpha,beta,gamma,delta, x * 43960 + x * 34766 + x * 20033 + x * 11851, SDS PAGE, amino acid sequences Pyrococcus furiosus
34766
-
 alpha,beta,gamma,delta, x * 43960 + x * 34766 + x * 20033 + x * 11851, SDS PAGE, amino acid sequences Pyrococcus furiosus
43960
-
 alpha,beta,gamma,delta, x * 43960 + x * 34766 + x * 20033 + x * 11851, SDS PAGE, amino acid sequences Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pyrococcus furiosus enzyme catalyses the CoA-dependent oxidation of branched-chain 2-ketoacids ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + 2 H+ this enzyme is one of four 2-oxoacid oxidoreductases: indolepyruvate oxidoreductase, EC 1.2.7.8, pyruvate oxidoreductase, EC 1.2.7.1., 2-oxogluterate oxidoreductase, EC 1.2.7.3 Pyrococcus furiosus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme catalyses the CoA-dependent oxidation of branched-chain 2-ketoacids Pyrococcus furiosus ?
-
 ?

Subunits

Subunits Comment Organism
? alpha,beta,gamma,delta, x * 43960 + x * 34766 + x * 20033 + x * 11851, SDS PAGE, amino acid sequences Pyrococcus furiosus