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Literature summary for 1.2.7.4 extracted from

  • Tan, X.; Lindahl, P.A.
    Tunnel mutagenesis and Ni-dependent reduction and methylation of the alpha subunit of acetyl coenzyme A synthase/carbon monoxide dehydrogenase (2008), J. Biol. Inorg. Chem., 13, 771-778.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Moorella thermoacetica

Protein Variants

Protein Variants Comment Organism
A110C alpha subunit mutant enzyme showing electron paramagnetic resonance spectrum after Ni-activation Moorella thermoacetica
A222L alpha subunit mutant enzyme showing electron paramagnetic resonance spectrum after Ni-activation Moorella thermoacetica

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ activates Moorella thermoacetica

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Moorella thermoacetica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO + H2O + acceptor
-
Moorella thermoacetica CO2 + reduced acceptor
-
?

Synonyms

Synonyms Comment Organism
acetyl coenzyme A synthase/carbon monoxide dehydrogenase
-
Moorella thermoacetica
ACS/CODH
-
Moorella thermoacetica
CODH beta subunit of the bifunctional acetyl coenzyme A synthase/carbon monoxide dehydrogenase complex Moorella thermoacetica

Cofactor

Cofactor Comment Organism Structure
Ni-Fe-4S center active site called the C-cluster Moorella thermoacetica