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Literature summary for 1.2.7.12 extracted from

  • Vorholt, J.A.; Thauer, R.K.
    The active species of 'CO2' utilized by formylmethanofuran dehydrogenase from Methanogenic archaea (1997), Eur. J. Biochem., 248, 919-924.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formylmethanofuran + oxidized acceptor Methanosarcina barkeri formation of formylmethanofuran, which is an intermediate in methanogenesis from CO2 ?
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Organism

Organism UniProt Comment Textmining
Methanosarcina barkeri
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Methanothermobacter thermautotrophicus
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Reaction

Reaction Comment Organism Reaction ID
a formylmethanofuran + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO2 + a methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ the enzyme catalyzes a methanofuran-dependent exchange between CO2 and the formyl group of formylmethanofuran, N-carboxymethanofuran is an intermediate in CO2 reduction to formylmethanofuran Methanosarcina barkeri

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formylmethanofuran + oxidized acceptor formation of formylmethanofuran, which is an intermediate in methanogenesis from CO2 Methanosarcina barkeri ?
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formylmethanofuran + oxidized benzylviologen + H2O
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Methanothermobacter thermautotrophicus methanofuran + reduced benzylviologen + CO2
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?
formylmethanofuran + oxidized benzylviologen + H2O r Methanosarcina barkeri methanofuran + reduced benzylviologen + CO2
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