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Literature summary for 1.2.5.3 extracted from

  • Schubel, U.; Kraut, M.; Morsdorf, G.; Meyer, O.
    Molecular characterization of the gene cluster coxMSL encoding the molybdenum-containing carbon monoxide dehydrogenase of Oligotropha carboxidovorans (1995), J. Bacteriol., 177, 2197-2203.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
large, medium, and small subunits of CODH are encoded by the structural genes coxL, coxM, and coxS, respectively. They reside on a 128-kb megaplasmid pHCG3, DNA and amino acid sequence determination and analysis, and molecular organization of the coxMSL gene cluster, sequence comparisons Afipia carboxidovorans

Metals/Ions

Metals/Ions Comment Organism Structure
Molybdenum
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Afipia carboxidovorans
[2Fe-2S] cluster two distinct [2Fe-2S] clusters, the small subunit CoxS contains motifs indicative of type I and II [2Fe-2S] cluster, structure and binding strutcures, overview Afipia carboxidovorans

Organism

Organism UniProt Comment Textmining
Afipia carboxidovorans P19919 and P19920 and P19921 large, medium, and small subunits; large, medium, and small subunits of CODH are encoded by the structural genes coxL, coxM, and coxS, respectively. They reside on the 128-kb megaplasmid pHCG3
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Afipia carboxidovorans OM5 P19919 and P19920 and P19921 large, medium, and small subunits; large, medium, and small subunits of CODH are encoded by the structural genes coxL, coxM, and coxS, respectively. They reside on the 128-kb megaplasmid pHCG3
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Synonyms

Synonyms Comment Organism
CODH
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Afipia carboxidovorans
molybdenum-containing carbon monoxide dehydrogenase
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Afipia carboxidovorans

Cofactor

Cofactor Comment Organism Structure
FAD the GLGTYG sequence, residues 564 to 569, in large subunit CoxL is identical to dinucleotide-binding motif GXGXXG/A, an FAD binding site. The FAD-binding domain of the ferredoxin-NADP+ reductase type is absent Afipia carboxidovorans
molybdenum cofactor
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Afipia carboxidovorans

General Information

General Information Comment Organism
physiological function the enzyme is a molybdenum-containing iron-sulfur flavoprotein and is the key enzyme in the chemolithoautotrophic utilization of CO by Oligotropha carboxidovorans strain OM5. Conserved protein building blocks constitute CODH and the other molybdenum hydroxylases Afipia carboxidovorans