Literature summary for 1.2.4.4 extracted from

Hull, J.; Usmari Moraes, M.; Brookes, E.; Love, S.; Conway, M.
Distribution of the branched-chain alpha-ketoacid dehydrogenase complex E1alpha subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism (2018), Neurochem. Int., 112, 49-58 .

Search for more literature for 1.2.4.4

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	A0A024R0K3	subunit alpha	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	predominantly in neuropil and neurons throughout the brain	Homo sapiens	-
neuron	-	Homo sapiens	-
vascular endothelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
2-oxoisovalerate dehydrogenase subunit alpha	-	Homo sapiens
BCKDHA	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	branched-chain amino acids are metabolized within both the vasculature and neurons in the human brain. Glutamate dehydrogenase isozymes, branched-chain aminotransferase and the branched-chain alpha-ketoacid dehydrogenase proteins may operate in conjunction with astrocytic glutamate transporters and glutamine synthetase to regulate the availability of glutamate	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)