Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activated by dephosphorylation | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | regulation of BCKD kinase expression by nutritional, hormonal, and pathological factors | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-Ketoisocaproate | allosteric inhibition, also by other branched-chain keto acids, although they are less effective as compared to alpha-ketoisocaproate | Homo sapiens | |
additional information | inhibited by phosphorylation, allosteric inhibition by CoA esters that arise during branched-chain amino acid catabolism | Homo sapiens | |
NADH | active dephosphorylated BCKD, allosteric inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
heart | lowest activity | Homo sapiens | - |
intestine | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
skeletal muscle | highest activity | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | flux-generating step for branched-chain amino acid catabolism | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCKD | - |
Homo sapiens |
branched-chain alpha-keto acid dehydrogenase | - |
Homo sapiens |