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Literature summary for 1.2.4.4 extracted from

  • Brosnan, J.T.; Brosnan, M.E.
    Branched-chain amino acids: enzyme and substrate regulation (2006), J. Nutr., 136, 207S-211S.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activated by dephosphorylation Homo sapiens

Application

Application Comment Organism
additional information regulation of BCKD kinase expression by nutritional, hormonal, and pathological factors Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-Ketoisocaproate allosteric inhibition, also by other branched-chain keto acids, although they are less effective as compared to alpha-ketoisocaproate Homo sapiens
additional information inhibited by phosphorylation, allosteric inhibition by CoA esters that arise during branched-chain amino acid catabolism Homo sapiens
NADH active dephosphorylated BCKD, allosteric inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Homo sapiens
-
brain
-
Homo sapiens
-
heart lowest activity Homo sapiens
-
intestine
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
skeletal muscle highest activity Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information flux-generating step for branched-chain amino acid catabolism Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
BCKD
-
Homo sapiens
branched-chain alpha-keto acid dehydrogenase
-
Homo sapiens