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Literature summary for 1.2.4.2 extracted from
- Catalytic domain of Salmonella typhimurium 2-oxoglutarate dehydrogenase is localized in N-terminal region (2003), J. Mol. Catal. B, 26, 193-200.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ogdh, library screening, complementation of an enzyme-deficient Escherichia coli mutant strain JRG72, DNA and amino acid sequence determination and analysis, functional expression of full-length enzyme and N-terminal catalytic domain in Escherichia coli strain JM109 | Salmonella enterica subsp. enterica serovar Typhimurium |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
x * 110000, about, E1o component, sequence calculation, x * 30000, recombinant N-terminal catalytic domain, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
| 110000 | - |
x * 110000, about, E1o component, sequence calculation, x * 30000, recombinant N-terminal catalytic domain, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Salmonella enterica subsp. enterica serovar Typhimurium | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica subsp. enterica serovar Typhimurium | O87668 | strain ATCC 14028, gene ogdh, enzyme E1o is a component of the 2-oxoglutarate dehydrogenase multienzyme complex | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Salmonella enterica subsp. enterica serovar Typhimurium | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 110000, about, E1o component, sequence calculation, x * 30000, recombinant N-terminal catalytic domain, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
| More | the catalytic domain of E1o is located at the N-terminus | Salmonella enterica subsp. enterica serovar Typhimurium |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 2-oxoglutarate dehydrogenase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| E1o | component of the 2-oxoglutarate dehydrogenase multienzyme complex | Salmonella enterica subsp. enterica serovar Typhimurium |
| OGDH | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| thiamine diphosphate | prosthetic group | Salmonella enterica subsp. enterica serovar Typhimurium | |
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