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Literature summary for 1.2.4.2 extracted from

  • Nulton-Persson, A.C.; Starke, D.W.; Mieyal, J.J.; Szweda, L.I.
    Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status (2003), Biochemistry, 42, 4235-4242.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glutathione regulation of enzyme activity by reversible glutathionylation, modulation of function by redox status Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
glutathione regulation of enzyme activity by reversible glutathionylation, inactivation with diamide Rattus norvegicus
additional information treatment of mitochondria with H2O2 or tert-butylhydroperoxide leads to decreased enzyme activity due to alterations in the glutathione status, reversible inhibition in case of H2O2, irrevrsible in case of tert-butylhydroperoxide, no direct interaction and no inhibition of isolated enzyme, inhibitory mechanism, enzyme reactivation by DTT, glutathione, and the glutaredoxin system, but not by thioredoxin system Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane associated with Rattus norvegicus 5743
-
mitochondrion subsarcolemmal Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
partially, isolation of subsarcolemmal mitochondria from heart Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation pure enzyme Rattus norvegicus
-
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir

Synonyms

Synonyms Comment Organism
alpha-ketoglutarate dehydrogenase
-
Rattus norvegicus
KGDH
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus