Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | regulation of enzyme activity by reversible glutathionylation, modulation of function by redox status | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glutathione | regulation of enzyme activity by reversible glutathionylation, inactivation with diamide | Rattus norvegicus | |
additional information | treatment of mitochondria with H2O2 or tert-butylhydroperoxide leads to decreased enzyme activity due to alterations in the glutathione status, reversible inhibition in case of H2O2, irrevrsible in case of tert-butylhydroperoxide, no direct interaction and no inhibition of isolated enzyme, inhibitory mechanism, enzyme reactivation by DTT, glutathione, and the glutaredoxin system, but not by thioredoxin system | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | associated with | Rattus norvegicus | 5743 | - |
mitochondrion | subsarcolemmal | Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Purification (Comment) | Organism |
---|---|
partially, isolation of subsarcolemmal mitochondria from heart | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | pure enzyme | Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
alpha-ketoglutarate dehydrogenase | - |
Rattus norvegicus |
KGDH | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |