Literature summary for 1.2.3.1 extracted from

Nirogi, R.; Kandikere, V.; Palacharla, R.C.; Bhyrapuneni, G.; Kanamarlapudi, V.B.; Ponnamaneni, R.K.; Manoharan, A.K.
Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions (2014), Xenobiotica, 44, 197-204.

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Activating Compound

Activating Compound	Comment	Organism	Structure
hydralazine	stimulation of activity at high and low concentrations	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
estradiol	uncompetitive, with no inhibition towards the tested CYP450 enzymes	Homo sapiens
quetiapine	additionally shows inhibition towards the major CYP450 enzymes tested	Homo sapiens
raloxifene	additionally acts as non-specific inhibitor of all major tested CYP450 enzymes	Homo sapiens

Organic Solvent Stability

Organic Solvent	Comment	Organism
acetonitrile	inhibitory above 0.5% v/v	Homo sapiens
DMSO	inhibitory above 0.5% v/v	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00009	-	pH 7.4, 37°C	Homo sapiens	raloxifene
0.00062	-	pH 7.4, 37°C	Homo sapiens	estradiol
0.00094	-	pH 7.4, 37°C	Homo sapiens	quetiapine

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Release 2023.1 (January 2023)