Inhibitors | Comment | Organism | Structure |
---|---|---|---|
raloxifene | inhibits substrate binding at the molybdenum site of the enzyme | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0096 | - |
4-(dimethylamino)cinnamaldehyde | in the presence of 1 mM nitrite, at pH 6.0 and 37°C | Rattus norvegicus | |
0.024 | - |
NADH | in the presence of 1 mM nitrite, at pH 6.0 and 37°C | Rattus norvegicus | |
2.7 | - |
nitrite | in the presence of 0.1 mM NADH, at pH 6.0 and 37°C | Rattus norvegicus | |
3.3 | - |
nitrite | in the presence of 0.05 mM 4-(dimethylamino)cinnamaldehyde, at pH 6.0 and 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(dimethylamino)cinnamaldehyde + H2O + O2 | - |
Rattus norvegicus | ? | - |
? | |
4-(dimethylamino)cinnamaldehyde + nitrite + H2O + O2 | in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide | Rattus norvegicus | ? + nitric oxide | - |
? | |
NADH + nitrite + H2O + O2 | in the presence of typical aldehyde substrates like 4-(dimethylamino)cinnamaldehyde or NADH, aldehyde oxidase reduces nitrite to nitric oxide. NADH reacts with aldehyde oxidase at the FAD site of the enzyme | Rattus norvegicus | ? + nitric oxide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldehyde:oxygen oxidoreductase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
maximum aldehyde oxidase-catalyzed nitric oxide generation occurs at pH 6.0 | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 8 | maximum aldehyde oxidase-catalyzed nitric oxide generation occurs at pH 6.0. When the pH is decreased to 5.0 or increased above 8.0, a decrease in the rate of nitric oxide generation is observed | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus |