Literature summary for 1.2.3.1 extracted from

Pirouzpanah, S.; Hanaee, J.; Razavieh, S.V.; Rashidi, M.R.
Inhibitory effects of flavonoids on aldehyde oxidase activity (2009), J. Enzyme Inhib. Med. Chem., 24, 14-21.

Activating Compound

Activating Compound	Comment	Organism	Structure
menadione	inhibitory versus substrates vanillin and phenanthridine, activating versus substrate xanthine	Cavia porcellus

Inhibitors

Inhibitors	Comment	Organism
(+)-catechin	-	Cavia porcellus
(-)-epicatechin	-	Cavia porcellus
hesperetin	-	Cavia porcellus
menadione	inhibitory versus substrates vanillin and phenanthridine, activating versus substrate xanthine	Cavia porcellus
additional information	oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine. A rather plan structure is essential for a potent inhibitory effect and substitution by sugar moieties reduces the inhibitory effects	Cavia porcellus
morin	-	Cavia porcellus
myricetin	inhibition of both aldehyde oxidase and xanthine oxidase	Cavia porcellus
naringenin	-	Cavia porcellus
quercetin	inhibition of both aldehyde oxidase and xanthine oxidase	Cavia porcellus
taxifolin	-	Cavia porcellus

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Cavia porcellus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Cavia porcellus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
phenanthridine + H2O + O2	oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine	Cavia porcellus	6-phenantridone + H2O2	-	?
vanillin + H2O + O2	oxidation of vanillin is more sensitive to inhibition by flavonoids than that of phenanthridine	Cavia porcellus	vanillic acid + H2O2	-	?
xanthine + H2O + O2	-	Cavia porcellus	? + H2O2	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0004	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	quercetin
0.0004	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	menadione
0.0004	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	myricetin
0.0004	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	myricetin
0.0007	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	quercetin
0.0007	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	quercetin
0.0019	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	menadione
0.0021	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	myricetin
0.0025	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	(+)-catechin
0.0034	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	naringenin
0.0037	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	morin
0.0041	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	taxifolin
0.0043	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	hesperetin
0.0057	-	substrate vanillin, pH 7.0, 37°C	Cavia porcellus	(-)-epicatechin
0.0061	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	(-)-epicatechin
0.0061	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	(+)-catechin
0.0069	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	morin
0.0088	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	naringenin
0.0098	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	hesperetin
0.0147	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	taxifolin
0.0251	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	naringenin
0.0266	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	hesperetin
0.0285	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	taxifolin
0.0301	-	substrate phenanthridine, pH 7.0, 37°C	Cavia porcellus	morin
0.0592	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	(-)-epicatechin
0.0709	-	substrate xanthine, pH 7.0, 37°C	Cavia porcellus	(+)-catechin