Literature summary for 1.2.3.1 extracted from

Sigruener, A.; Buechler, C.; Orso, E.; Hartmann, A.; Wild, P.J.; Terracciano, L.; Roncalli, M.; Bornstein, S.R.; Schmitz, G.
Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes (2007), Horm. Metab. Res., 39, 781-789.

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Application

Application	Comment	Organism
medicine	significant correlations between reduced AOX1 expression and tumor stage, or metastatic or regional lymph node states. Reduced expression of AOX1 in malignant transformed hepatocytes supports the differentiation dependent upregulation of AOX1	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
siRNA	knock-down of AOX1 in HepG2 cells, significantly reduces ABCA1-dependent lipid efflux and enhances phagocytic uptake of microspheres similar to ABCA1 deficiency, without affecting ABCA1 mRNA and protein levels	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q06278	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	significantly expressed	Homo sapiens	-
brain	weak expression	Homo sapiens	-
heart	weak expression	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-
hepatocyte	ABCA1 and AOX1 are coexpressed	Homo sapiens	-
kidney	significantly expressed	Homo sapiens	-
Leydig cell	ABCA1 and AOX1 are coexpressed	Homo sapiens	-
liver	strong AOX1 expression in normal liver, and in cirrhosis. Hepatocellular carcinomas show either a complete loss or reduced expression of AOX1	Homo sapiens	-
lung	weak expression	Homo sapiens	-
additional information	in adrenocortical cells, ABCA1 and AOX1 are coexpressed. Absent from skeletal muscle, small intestine, MCF-7, PC3, CaCo-2, and HT-29 cells	Homo sapiens	-
ovary	significantly expressed	Homo sapiens	-
renal proximal tubule	in kidney proximal tubular epithelial cells, ABCA1 and AOX1 are coexpressed	Homo sapiens	-
spleen	weak expression	Homo sapiens	-
stomach	weak expression	Homo sapiens	-
testis	significantly expressed	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
aldehyde oxidase 1	-	Homo sapiens
AOX1	-	Homo sapiens

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Release 2023.1 (January 2023)