Cloned (Comment) | Organism |
---|---|
expression in ERscherichia coli | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.43 | - |
S-carboxymethyl-L-cysteine | pH 8.8, 37°C | Saccharomyces cerevisiae | |
0.47 | - |
L-2-aminoadipate | pH 8.8, 37°C | Saccharomyces cerevisiae | |
0.62 | - |
NADPH | pH 8.8, 37°C | Saccharomyces cerevisiae | |
2.7 | - |
D-2-aminoadipate | pH 8.8, 37°C | Saccharomyces cerevisiae | |
10 | - |
adipate | pH 8.8, 37°C | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
155000 | - |
x * 155000, calculated | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P07702 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | residue Ser880 is modified by phosphopantetheinylate, leading to activiation of the enzyme. Protein Lys5 catalyzes the modification using coenzyme A | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adipate + NADPH + H+ + ATP | - |
Saccharomyces cerevisiae | adipate semialdehyde + NADP+ + AMP + diphosphate | - |
? | |
D-2-aminoadipate + NADPH + H+ + ATP | - |
Saccharomyces cerevisiae | (R)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate | - |
? | |
L-2-aminoadipate + NADPH + H+ + ATP | - |
Saccharomyces cerevisiae | (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate | - |
? | |
S-carboxymethyl-L-cysteine + NADPH + H+ + ATP | - |
Saccharomyces cerevisiae | S-formylmethyl-L-cysteine + NADP+ + AMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 155000, calculated | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
LYS2 | - |
Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0045 | - |
adipate | pH 8.8, 37°C | Saccharomyces cerevisiae | |
0.63 | - |
D-2-aminoadipate | pH 8.8, 37°C | Saccharomyces cerevisiae | |
6 | - |
S-carboxymethyl-L-cysteine | pH 8.8, 37°C | Saccharomyces cerevisiae | |
41.7 | - |
L-2-aminoadipate | pH 8.8, 37°C | Saccharomyces cerevisiae |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
adipate | pH 8.8, 37°C | Saccharomyces cerevisiae | |
0.23 | - |
D-2-aminoadipate | pH 8.8, 37°C | Saccharomyces cerevisiae | |
14 | - |
S-carboxymethyl-L-cysteine | pH 8.8, 37°C | Saccharomyces cerevisiae | |
88.3 | - |
L-2-aminoadipate | pH 8.8, 37°C | Saccharomyces cerevisiae |