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Literature summary for 1.2.1.84 extracted from

  • Honsho, M.; Abe, Y.; Fujiki, Y.
    Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes (2017), Sci. Rep., 7, 43936.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WVX9
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens abrogation of the asymmetric distribution of plasmalogens in the plasma membrane by reducing the expression of CDC50A encoding a beta-subunit of flippase elevates the expression level of Far1 and plasmalogen synthesis without reducing the total cellular level of plasmalogens up

General Information

General Information Comment Organism
metabolism degradation of Far1 is accelerated by inhibiting dynamin-, Src kinase-, or flotillin-1-mediated endocytosis without increasing the cellular level of plasmalogens. Far1 is stabilized by sequestering cholesterol with nystatin Homo sapiens