Literature summary for 1.2.1.8 extracted from

Velasco-Garcia, R.; Chacon-Aguilar, V.M.; Hervert-Hernandez, D.; Munoz-Clares, R.A.
Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram (2003), Chem. Biol. Interact., 143-144, 149-158.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Disulfiram	inactivates in a time- and dose-dependent manner, inactivation kinetics is biphasic with second-order inactivation rate constants at pH 7.5 of 6.8 per M per sec and 0.33 per M per sec, inactivation is faster in presence of NAD(P)+ than in absence, inactivation is increased by NAD(P)H and betaine aldehyde, reactivation by dithiothreitol, inactivation is reversible by glutathione	Amaranthus hypochondriacus
Disulfiram	inactivates in a time- and dose-dependent manner, inactivation kinetics is monophasic with a second-order inactivation rate constant at pH 6.0 of 4.9 per M per sec and at pH 8.8 of 1000 per M per sec, inactivation is faster in presence of NAD(P)+ than in absence, inactivation is protected by NAD(P)H and betaine aldehyde, reactivation by dithiothreitol, inactivation is reversible by glutathione	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Amaranthus hypochondriacus	-	-	-
Pseudomonas aeruginosa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Pseudomonas aeruginosa	-
leaf	-	Amaranthus hypochondriacus	-

Synonyms

Synonyms	Comment	Organism
BADH	-	Pseudomonas aeruginosa
BADH	-	Amaranthus hypochondriacus

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Release 2023.1 (January 2023)