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Literature summary for 1.2.1.8 extracted from
- Porcine kidney betaine aldehyde dehydrogenase: purification and properties (1998), Comp. Biochem. Physiol. B, 119, 485-491.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | slight activation up to about 0.3 M | Sus scrofa |  |
| Pro | 0.1 M, 35% activation, at high substrate concentrations | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycine betaine | - |
Sus scrofa | |
| K+ | 1.0 mM, 35% inhibition | Sus scrofa | |
| Mg2+ | 0.4 M, complete inhibition | Sus scrofa | |
| NaCl | 40% inhibition above 0.3 M | Sus scrofa | |
| NH4+ | above 0.4 M, more than 60% inhibition | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
NAD+ | - |
Sus scrofa | |
| 0.127 | - |
Betaine aldehyde | - |
Sus scrofa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 0.2 M, slight activation | Sus scrofa | |
| Na+ | slight activation up to about 0.3 M | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
x * 52000, SDS-PAGE | Sus scrofa |
| 688000 | - |
non-denaturing PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Sus scrofa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for several months | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaldehyde + NAD+ + H2O | at 20% of the activity with betaine aldehyde | Sus scrofa | acetate + NADH + H+ | - |
? | |
| betaine aldehyde + NAD+ + H2O | - |
Sus scrofa | betaine + NADH | - |
ir | |
| butyraldehyde + NAD+ + H2O | at 40% of the activity with betaine aldehyde | Sus scrofa | butyrate + NADH | - |
? | |
| glyceraldehyde + NAD+ + H2O | at 30% of the activity with betaine aldehyde | Sus scrofa | glycerate + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 52000, SDS-PAGE | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | - |
- |
Sus scrofa |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9.5 | stable | Sus scrofa |
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Release 2023.1 (January 2023)
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